MovDisordV3, Main, Exploration, bibRecord, 001202

Association of Tef Polymorphism With Depression in Parkinson Disease

Identifieur interne : 001202 ( Main/Exploration ); précédent : 001201; suivant : 001203

Association of Tef Polymorphism With Depression in Parkinson Disease

Source :

Movement disorders [ 0885-3185 ] ; 2012.

RBID : Pascal:13-0017975

Descripteurs français

Pascal (Inist)
- Etat dépressif, Maladie de Parkinson, Pathologie du système nerveux, Polymorphisme, Rythme circadien.

English descriptors

KwdEn :
- Circadian rhythm, Depression, Nervous system diseases, Parkinson disease, Polymorphism.

Abstract

Background: Circadian rhythm disturbance has been implicated in depression, and polymorphisms of circadian genes Cry1, Cry2, and Tef are associated with depression. However, the relationship between these genes and depression symptoms in Parkinson's disease (PD) has not been established. Methods: Four hundred eight subjects with PD participated in this study. Demographics, UPDRS, Mini-Mental Status Examination (MMSE), and Hamilton Rating Scale for Depression (HAMD) were obtained in all subjects. Frequency of polymorphisms of Cry1 rs2287161, Cry2 rs10838524, and Tef rs738499 was determined, and the association between genetic polymorphisms of circadian genes and HAMD scores in patients with PD was examined. Results: Tef, but not Cry1 or Cry2, is associated with HAMD scores in patients with PD in a linear regression model after adjusting for clinical variables (P = 0.004). Conclusions: The polymorphism of Tef rs738499 is associated with depression symptoms in PD.

Affiliations:

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Le document en format XML

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<orgName type="university">Université Columbia</orgName>
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<author><name sortKey="Suwan Guo" sort="Suwan Guo" uniqKey="Suwan Guo" last="Suwan Guo">SUWAN GUO</name>
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<s2>Nanjing</s2>
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<author><name sortKey="Li Wang" sort="Li Wang" uniqKey="Li Wang" last="Li Wang">LI WANG</name>
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<author><name sortKey="Kwan, Justin Y" sort="Kwan, Justin Y" uniqKey="Kwan J" first="Justin Y." last="Kwan">Justin Y. Kwan</name>
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<s2>Baltimore, Maryland</s2>
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<country>États-Unis</country>
<placeName><region type="state">Maryland</region>
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<author><name sortKey="Tianxia Wu" sort="Tianxia Wu" uniqKey="Tianxia Wu" last="Tianxia Wu">TIANXIA WU</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Association of Tef Polymorphism With Depression in Parkinson Disease</title>
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<author><name sortKey="Weiguo Liu" sort="Weiguo Liu" uniqKey="Weiguo Liu" last="Weiguo Liu">WEIGUO LIU</name>
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<s2>Nanjing</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
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<wicri:noRegion>Nanjing</wicri:noRegion>
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</author>
<author><name sortKey="Kuo, Sheng Han" sort="Kuo, Sheng Han" uniqKey="Kuo S" first="Sheng-Han" last="Kuo">Sheng-Han Kuo</name>
<affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Neurology, College of Physicians and Surgeons, Columbia University</s1>
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</inist:fA14>
<country>États-Unis</country>
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<settlement type="city">New York</settlement>
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<orgName type="university">Université Columbia</orgName>
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<author><name sortKey="Yanyan Zhao" sort="Yanyan Zhao" uniqKey="Yanyan Zhao" last="Yanyan Zhao">YANYAN ZHAO</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Affiliated Brain Hospital of Nanjing Medical University</s1>
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<s3>CHN</s3>
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<wicri:noRegion>Nanjing</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ling Chen" sort="Ling Chen" uniqKey="Ling Chen" last="Ling Chen">LING CHEN</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Medical Psychology, Affiliated Brain Hospital of Nanjing Medical University</s1>
<s2>Nanjing</s2>
<s3>CHN</s3>
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<wicri:noRegion>Nanjing</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ning Zhang" sort="Ning Zhang" uniqKey="Ning Zhang" last="Ning Zhang">NING ZHANG</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Medical Psychology, Affiliated Brain Hospital of Nanjing Medical University</s1>
<s2>Nanjing</s2>
<s3>CHN</s3>
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<sZ>6 aut.</sZ>
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<wicri:noRegion>Nanjing</wicri:noRegion>
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</author>
<author><name sortKey="Chun Wang" sort="Chun Wang" uniqKey="Chun Wang" last="Chun Wang">CHUN WANG</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Medical Psychology, Affiliated Brain Hospital of Nanjing Medical University</s1>
<s2>Nanjing</s2>
<s3>CHN</s3>
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<author><name sortKey="Suwan Guo" sort="Suwan Guo" uniqKey="Suwan Guo" last="Suwan Guo">SUWAN GUO</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Medical Psychology, Affiliated Brain Hospital of Nanjing Medical University</s1>
<s2>Nanjing</s2>
<s3>CHN</s3>
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<sZ>6 aut.</sZ>
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<country>République populaire de Chine</country>
<wicri:noRegion>Nanjing</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Li Wang" sort="Li Wang" uniqKey="Li Wang" last="Li Wang">LI WANG</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Clinical Laboratory, Affiliated Brain Hospital of Nanjing Medical University</s1>
<s2>Nanjing</s2>
<s3>CHN</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
<wicri:noRegion>Nanjing</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hong Xiao" sort="Hong Xiao" uniqKey="Hong Xiao" last="Hong Xiao">HONG XIAO</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Institute of Scientific Research, Affiliated Brain Hospital of Nanjing Medical University</s1>
<s2>Nanjing</s2>
<s3>CHN</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
<wicri:noRegion>Nanjing</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kwan, Justin Y" sort="Kwan, Justin Y" uniqKey="Kwan J" first="Justin Y." last="Kwan">Justin Y. Kwan</name>
<affiliation wicri:level="2"><inist:fA14 i1="06"><s1>Department of Neurology, University of Maryland</s1>
<s2>Baltimore, Maryland</s2>
<s3>USA</s3>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tianxia Wu" sort="Tianxia Wu" uniqKey="Tianxia Wu" last="Tianxia Wu">TIANXIA WU</name>
<affiliation wicri:level="2"><inist:fA14 i1="07"><s1>National Institute of Neurological Diseases and Stroke, National Institutes of Health</s1>
<s2>Bethesda, Maryland</s2>
<s3>USA</s3>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2012">2012</date>
</imprint>
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</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Circadian rhythm</term>
<term>Depression</term>
<term>Nervous system diseases</term>
<term>Parkinson disease</term>
<term>Polymorphism</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Etat dépressif</term>
<term>Maladie de Parkinson</term>
<term>Pathologie du   système nerveux</term>
<term>Polymorphisme</term>
<term>Rythme circadien</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Background: Circadian rhythm disturbance has been implicated in depression, and polymorphisms of circadian genes Cry1, Cry2, and Tef are associated with depression. However, the relationship between these genes and depression symptoms in Parkinson's disease (PD) has not been established. Methods: Four hundred eight subjects with PD participated in this study. Demographics, UPDRS, Mini-Mental Status Examination (MMSE), and Hamilton Rating Scale for Depression (HAMD) were obtained in all subjects. Frequency of polymorphisms of Cry1 rs2287161, Cry2 rs10838524, and Tef rs738499 was determined, and the association between genetic polymorphisms of circadian genes and HAMD scores in patients with PD was examined. Results: Tef, but not Cry1 or Cry2, is associated with HAMD scores in patients with PD in a linear regression model after adjusting for clinical variables (P = 0.004). Conclusions: The polymorphism of Tef rs738499 is associated with depression symptoms in PD.</div>
</front>
</TEI>
<affiliations><list><country><li>République populaire de Chine</li>
<li>États-Unis</li>
</country>
<region><li>Maryland</li>
<li>État de New York</li>
</region>
<settlement><li>New York</li>
</settlement>
<orgName><li>Université Columbia</li>
</orgName>
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<tree><country name="République populaire de Chine"><noRegion><name sortKey="Ping Hua" sort="Ping Hua" uniqKey="Ping Hua" last="Ping Hua">PING HUA</name>
</noRegion>
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<name sortKey="Hong Xiao" sort="Hong Xiao" uniqKey="Hong Xiao" last="Hong Xiao">HONG XIAO</name>
<name sortKey="Li Wang" sort="Li Wang" uniqKey="Li Wang" last="Li Wang">LI WANG</name>
<name sortKey="Ling Chen" sort="Ling Chen" uniqKey="Ling Chen" last="Ling Chen">LING CHEN</name>
<name sortKey="Ning Zhang" sort="Ning Zhang" uniqKey="Ning Zhang" last="Ning Zhang">NING ZHANG</name>
<name sortKey="Suwan Guo" sort="Suwan Guo" uniqKey="Suwan Guo" last="Suwan Guo">SUWAN GUO</name>
<name sortKey="Weiguo Liu" sort="Weiguo Liu" uniqKey="Weiguo Liu" last="Weiguo Liu">WEIGUO LIU</name>
<name sortKey="Yanyan Zhao" sort="Yanyan Zhao" uniqKey="Yanyan Zhao" last="Yanyan Zhao">YANYAN ZHAO</name>
</country>
<country name="États-Unis"><region name="État de New York"><name sortKey="Kuo, Sheng Han" sort="Kuo, Sheng Han" uniqKey="Kuo S" first="Sheng-Han" last="Kuo">Sheng-Han Kuo</name>
</region>
<name sortKey="Kwan, Justin Y" sort="Kwan, Justin Y" uniqKey="Kwan J" first="Justin Y." last="Kwan">Justin Y. Kwan</name>
<name sortKey="Tianxia Wu" sort="Tianxia Wu" uniqKey="Tianxia Wu" last="Tianxia Wu">TIANXIA WU</name>
</country>
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</record>

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	Movement Disorders (revue)
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Movement Disorders (revue)

Association of Tef Polymorphism With Depression in Parkinson Disease

Association of Tef Polymorphism With Depression in Parkinson Disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri